GlutaredoxinV1, Main, Exploration, bibRecord, 000179

Deletion of glutaredoxin promotes oxidative tolerance and intracellular infection in Listeria monocytogenes.

Identifieur interne : 000179 ( Main/Exploration ); précédent : 000178; suivant : 000180

Deletion of glutaredoxin promotes oxidative tolerance and intracellular infection in Listeria monocytogenes.

Source :

Virulence [ 2150-5608 ] ; 2019.

RBID : pubmed:31680614

Descripteurs français

KwdFr :
- Animaux (MeSH), Cellules Caco-2 (MeSH), Cellules épithéliales (microbiologie), Cytoplasme (microbiologie), Délétion de gène (MeSH), Facteurs de virulence (MeSH), Femelle (MeSH), Fibroblastes (microbiologie), Glutarédoxines (génétique), Humains (MeSH), Infections à Listeria (microbiologie), Insuline (métabolisme), Lignée cellulaire (MeSH), Listeria monocytogenes (effets des médicaments et des substances chimiques), Listeria monocytogenes (génétique), Listeria monocytogenes (pathogénicité), Macrophages (microbiologie), Oxydants (pharmacologie), Protéines bactériennes (génétique), Souris (MeSH), Souris de lignée ICR (MeSH), Stress oxydatif (MeSH).
MESH :
- effets des médicaments et des substances chimiques : Listeria monocytogenes.
- génétique : Glutarédoxines, Listeria monocytogenes, Protéines bactériennes.
- microbiologie : Cellules épithéliales, Cytoplasme, Fibroblastes, Infections à Listeria, Macrophages.
- métabolisme : Insuline.
- pathogénicité : Listeria monocytogenes.
- pharmacologie : Oxydants.
- Animaux, Cellules Caco-2, Délétion de gène, Facteurs de virulence, Femelle, Humains, Lignée cellulaire, Souris, Souris de lignée ICR, Stress oxydatif.

English descriptors

KwdEn :
- Animals (MeSH), Bacterial Proteins (genetics), Caco-2 Cells (MeSH), Cell Line (MeSH), Cytoplasm (microbiology), Epithelial Cells (microbiology), Female (MeSH), Fibroblasts (microbiology), Gene Deletion (MeSH), Glutaredoxins (genetics), Humans (MeSH), Insulin (metabolism), Listeria monocytogenes (drug effects), Listeria monocytogenes (genetics), Listeria monocytogenes (pathogenicity), Listeriosis (microbiology), Macrophages (microbiology), Mice (MeSH), Mice, Inbred ICR (MeSH), Oxidants (pharmacology), Oxidative Stress (MeSH), Virulence Factors (MeSH).
MESH :
- chemical , genetics : Bacterial Proteins, Glutaredoxins.
- chemical , metabolism : Insulin.
- drug effects : Listeria monocytogenes.
- genetics : Listeria monocytogenes.
- microbiology : Cytoplasm, Epithelial Cells, Fibroblasts, Listeriosis, Macrophages.
- pathogenicity : Listeria monocytogenes.
- chemical , pharmacology : Oxidants.
- Animals, Caco-2 Cells, Cell Line, Female, Gene Deletion, Humans, Mice, Mice, Inbred ICR, Oxidative Stress, Virulence Factors.

Abstract

Thiol-disulfide glutaredoxin systems of bacterial cytoplasm favor reducing conditions for the correct disulfide bonding of functional proteins, and therefore were employed by bacteria to defend against oxidative stress. Listeria monocytogenes has been shown to encode a putative glutaredoxin, Grx (encoded by lmo2344), while the underlying roles remain unknown. Here we suggest an unexpected role of L. monocytogenes Grx in oxidative tolerance and intracellular infection. The recombinant Grx was able to efficiently catalyze the thiol-disulfide oxidoreduction of insulin in the presence of DTT as an election donor. Unexpectedly, the deletion of grx resulted in a remarkably increased tolerance and survival ability of this bacteria when exposed to various oxidizing agents, including diamide, and copper and cadmium ions. Furthermore, loss of grx significantly promoted bacterial invasion and proliferation in human epithelial Caco-2 cells and murine macrophages, as well as a notably increasing invasion but not cell-to-cell spread in the murine fibroblasts L929 cells. More importantly, L. monocytogenes lacking the glutaredoxin exhibited more efficient proliferation and recovery in the spleens and livers of the infected mice, and hence became more virulent by upregulating the virulence factors, InlA and InlB. In summary, we here for the first time demonstrated that L. monocytogenes glutaredoxin plays a counterintuitive role in bacterial oxidative resistance and intracellular infection, which is the first report to provide valuable evidence for the role of glutaredoxins in bacterial infection, and more importantly suggests a favorable model to illustrate the functional diversity of bacterial Grx systems during environmental adaption and host infection.

DOI: 10.1080/21505594.2019.1685640
PubMed: 31680614
PubMed Central: PMC6844310

Affiliations:

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Le document en format XML

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<author><name sortKey="Chen, Zhongwei" sort="Chen, Zhongwei" uniqKey="Chen Z" first="Zhongwei" last="Chen">Zhongwei Chen</name>
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<author><name sortKey="Shao, Chunyan" sort="Shao, Chunyan" uniqKey="Shao C" first="Chunyan" last="Shao">Chunyan Shao</name>
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<author><name sortKey="Yang, Yongchun" sort="Yang, Yongchun" uniqKey="Yang Y" first="Yongchun" last="Yang">Yongchun Yang</name>
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<author><name sortKey="Zhou, Yingshan" sort="Zhou, Yingshan" uniqKey="Zhou Y" first="Yingshan" last="Zhou">Yingshan Zhou</name>
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<author><name sortKey="Wang, Xiaodu" sort="Wang, Xiaodu" uniqKey="Wang X" first="Xiaodu" last="Wang">Xiaodu Wang</name>
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<placeName><settlement type="city">Hangzhou</settlement>
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<author><name sortKey="Cheng, Changyong" sort="Cheng, Changyong" uniqKey="Cheng C" first="Changyong" last="Cheng">Changyong Cheng</name>
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<placeName><settlement type="city">Hangzhou</settlement>
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<author><name sortKey="Song, Houhui" sort="Song, Houhui" uniqKey="Song H" first="Houhui" last="Song">Houhui Song</name>
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<placeName><settlement type="city">Hangzhou</settlement>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Deletion of glutaredoxin promotes oxidative tolerance and intracellular infection in <i>Listeria monocytogenes</i>
.</title>
<author><name sortKey="Sun, Jing" sort="Sun, Jing" uniqKey="Sun J" first="Jing" last="Sun">Jing Sun</name>
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<placeName><settlement type="city">Hangzhou</settlement>
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<author><name sortKey="Hang, Yi" sort="Hang, Yi" uniqKey="Hang Y" first="Yi" last="Hang">Yi Hang</name>
<affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</nlm:affiliation>
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<placeName><settlement type="city">Hangzhou</settlement>
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<author><name sortKey="Han, Yue" sort="Han, Yue" uniqKey="Han Y" first="Yue" last="Han">Yue Han</name>
<affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</nlm:affiliation>
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<placeName><settlement type="city">Hangzhou</settlement>
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</placeName>
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<author><name sortKey="Zhang, Xian" sort="Zhang, Xian" uniqKey="Zhang X" first="Xian" last="Zhang">Xian Zhang</name>
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<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
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</author>
<author><name sortKey="Gan, Li" sort="Gan, Li" uniqKey="Gan L" first="Li" last="Gan">Li Gan</name>
<affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
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<author><name sortKey="Cai, Chang" sort="Cai, Chang" uniqKey="Cai C" first="Chang" last="Cai">Chang Cai</name>
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<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>School of Veterinary and Life Sciences, Murdoch University, Murdoch, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
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<wicri:noRegion>Murdoch</wicri:noRegion>
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</author>
<author><name sortKey="Chen, Zhongwei" sort="Chen, Zhongwei" uniqKey="Chen Z" first="Zhongwei" last="Chen">Zhongwei Chen</name>
<affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</nlm:affiliation>
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<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Yang" sort="Yang, Yang" uniqKey="Yang Y" first="Yang" last="Yang">Yang Yang</name>
<affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Song, Quanjiang" sort="Song, Quanjiang" uniqKey="Song Q" first="Quanjiang" last="Song">Quanjiang Song</name>
<affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shao, Chunyan" sort="Shao, Chunyan" uniqKey="Shao C" first="Chunyan" last="Shao">Chunyan Shao</name>
<affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Yongchun" sort="Yang, Yongchun" uniqKey="Yang Y" first="Yongchun" last="Yang">Yongchun Yang</name>
<affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhou, Yingshan" sort="Zhou, Yingshan" uniqKey="Zhou Y" first="Yingshan" last="Zhou">Yingshan Zhou</name>
<affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Xiaodu" sort="Wang, Xiaodu" uniqKey="Wang X" first="Xiaodu" last="Wang">Xiaodu Wang</name>
<affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cheng, Changyong" sort="Cheng, Changyong" uniqKey="Cheng C" first="Changyong" last="Cheng">Changyong Cheng</name>
<affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Song, Houhui" sort="Song, Houhui" uniqKey="Song H" first="Houhui" last="Song">Houhui Song</name>
<affiliation wicri:level="3"><nlm:affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou</wicri:regionArea>
<placeName><settlement type="city">Hangzhou</settlement>
<region type="province">Zhejiang</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Virulence</title>
<idno type="eISSN">2150-5608</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term>
<term>Bacterial Proteins (genetics)</term>
<term>Caco-2 Cells (MeSH)</term>
<term>Cell Line (MeSH)</term>
<term>Cytoplasm (microbiology)</term>
<term>Epithelial Cells (microbiology)</term>
<term>Female (MeSH)</term>
<term>Fibroblasts (microbiology)</term>
<term>Gene Deletion (MeSH)</term>
<term>Glutaredoxins (genetics)</term>
<term>Humans (MeSH)</term>
<term>Insulin (metabolism)</term>
<term>Listeria monocytogenes (drug effects)</term>
<term>Listeria monocytogenes (genetics)</term>
<term>Listeria monocytogenes (pathogenicity)</term>
<term>Listeriosis (microbiology)</term>
<term>Macrophages (microbiology)</term>
<term>Mice (MeSH)</term>
<term>Mice, Inbred ICR (MeSH)</term>
<term>Oxidants (pharmacology)</term>
<term>Oxidative Stress (MeSH)</term>
<term>Virulence Factors (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Cellules Caco-2 (MeSH)</term>
<term>Cellules épithéliales (microbiologie)</term>
<term>Cytoplasme (microbiologie)</term>
<term>Délétion de gène (MeSH)</term>
<term>Facteurs de virulence (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Fibroblastes (microbiologie)</term>
<term>Glutarédoxines (génétique)</term>
<term>Humains (MeSH)</term>
<term>Infections à Listeria (microbiologie)</term>
<term>Insuline (métabolisme)</term>
<term>Lignée cellulaire (MeSH)</term>
<term>Listeria monocytogenes (effets des médicaments et des substances chimiques)</term>
<term>Listeria monocytogenes (génétique)</term>
<term>Listeria monocytogenes (pathogénicité)</term>
<term>Macrophages (microbiologie)</term>
<term>Oxydants (pharmacologie)</term>
<term>Protéines bactériennes (génétique)</term>
<term>Souris (MeSH)</term>
<term>Souris de lignée ICR (MeSH)</term>
<term>Stress oxydatif (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Bacterial Proteins</term>
<term>Glutaredoxins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Insulin</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Listeria monocytogenes</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Listeria monocytogenes</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Listeria monocytogenes</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glutarédoxines</term>
<term>Listeria monocytogenes</term>
<term>Protéines bactériennes</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Cellules épithéliales</term>
<term>Cytoplasme</term>
<term>Fibroblastes</term>
<term>Infections à Listeria</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Cytoplasm</term>
<term>Epithelial Cells</term>
<term>Fibroblasts</term>
<term>Listeriosis</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Insuline</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Listeria monocytogenes</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Listeria monocytogenes</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Oxydants</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Oxidants</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Caco-2 Cells</term>
<term>Cell Line</term>
<term>Female</term>
<term>Gene Deletion</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred ICR</term>
<term>Oxidative Stress</term>
<term>Virulence Factors</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules Caco-2</term>
<term>Délétion de gène</term>
<term>Facteurs de virulence</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Souris</term>
<term>Souris de lignée ICR</term>
<term>Stress oxydatif</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Thiol-disulfide glutaredoxin systems of bacterial cytoplasm favor reducing conditions for the correct disulfide bonding of functional proteins, and therefore were employed by bacteria to defend against oxidative stress. <i>Listeria monocytogenes</i>
 has been shown to encode a putative glutaredoxin, Grx (encoded by <i>lmo2344</i>
), while the underlying roles remain unknown. Here we suggest an unexpected role of <i>L. monocytogenes</i>
 Grx in oxidative tolerance and intracellular infection. The recombinant Grx was able to efficiently catalyze the thiol-disulfide oxidoreduction of insulin in the presence of DTT as an election donor. Unexpectedly, the deletion of <i>grx</i>
 resulted in a remarkably increased tolerance and survival ability of this bacteria when exposed to various oxidizing agents, including diamide, and copper and cadmium ions. Furthermore, loss of <i>grx</i>
 significantly promoted bacterial invasion and proliferation in human epithelial Caco-2 cells and murine macrophages, as well as a notably increasing invasion but not cell-to-cell spread in the murine fibroblasts L929 cells. More importantly, <i>L. monocytogenes</i>
 lacking the glutaredoxin exhibited more efficient proliferation and recovery in the spleens and livers of the infected mice, and hence became more virulent by upregulating the virulence factors, InlA and InlB. In summary, we here for the first time demonstrated that <i>L. monocytogenes</i>
 glutaredoxin plays a counterintuitive role in bacterial oxidative resistance and intracellular infection, which is the first report to provide valuable evidence for the role of glutaredoxins in bacterial infection, and more importantly suggests a favorable model to illustrate the functional diversity of bacterial Grx systems during environmental adaption and host infection.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31680614</PMID>
<DateCompleted><Year>2020</Year>
<Month>08</Month>
<Day>03</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>08</Month>
<Day>03</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2150-5608</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>10</Volume>
<Issue>1</Issue>
<PubDate><Year>2019</Year>
<Month>12</Month>
</PubDate>
</JournalIssue>
<Title>Virulence</Title>
<ISOAbbreviation>Virulence</ISOAbbreviation>
</Journal>
<ArticleTitle>Deletion of glutaredoxin promotes oxidative tolerance and intracellular infection in <i>Listeria monocytogenes</i>
.</ArticleTitle>
<Pagination><MedlinePgn>910-924</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1080/21505594.2019.1685640</ELocationID>
<Abstract><AbstractText>Thiol-disulfide glutaredoxin systems of bacterial cytoplasm favor reducing conditions for the correct disulfide bonding of functional proteins, and therefore were employed by bacteria to defend against oxidative stress. <i>Listeria monocytogenes</i>
 has been shown to encode a putative glutaredoxin, Grx (encoded by <i>lmo2344</i>
), while the underlying roles remain unknown. Here we suggest an unexpected role of <i>L. monocytogenes</i>
 Grx in oxidative tolerance and intracellular infection. The recombinant Grx was able to efficiently catalyze the thiol-disulfide oxidoreduction of insulin in the presence of DTT as an election donor. Unexpectedly, the deletion of <i>grx</i>
 resulted in a remarkably increased tolerance and survival ability of this bacteria when exposed to various oxidizing agents, including diamide, and copper and cadmium ions. Furthermore, loss of <i>grx</i>
 significantly promoted bacterial invasion and proliferation in human epithelial Caco-2 cells and murine macrophages, as well as a notably increasing invasion but not cell-to-cell spread in the murine fibroblasts L929 cells. More importantly, <i>L. monocytogenes</i>
 lacking the glutaredoxin exhibited more efficient proliferation and recovery in the spleens and livers of the infected mice, and hence became more virulent by upregulating the virulence factors, InlA and InlB. In summary, we here for the first time demonstrated that <i>L. monocytogenes</i>
 glutaredoxin plays a counterintuitive role in bacterial oxidative resistance and intracellular infection, which is the first report to provide valuable evidence for the role of glutaredoxins in bacterial infection, and more importantly suggests a favorable model to illustrate the functional diversity of bacterial Grx systems during environmental adaption and host infection.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sun</LastName>
<ForeName>Jing</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hang</LastName>
<ForeName>Yi</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Han</LastName>
<ForeName>Yue</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Xian</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gan</LastName>
<ForeName>Li</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cai</LastName>
<ForeName>Chang</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>School of Veterinary and Life Sciences, Murdoch University, Murdoch, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Zhongwei</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Yang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Song</LastName>
<ForeName>Quanjiang</ForeName>
<Initials>Q</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shao</LastName>
<ForeName>Chunyan</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Yongchun</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Yingshan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Xiaodu</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China.</Affiliation>
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   |texte=   Deletion of glutaredoxin promotes oxidative tolerance and intracellular infection in Listeria monocytogenes.
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	Serveur d'exploration sur la glutarédoxine
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Serveur d'exploration sur la glutarédoxine

Deletion of glutaredoxin promotes oxidative tolerance and intracellular infection in Listeria monocytogenes.

Deletion of glutaredoxin promotes oxidative tolerance and intracellular infection in Listeria monocytogenes.

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